Pertussis hospitalizations among Oregon infants, february 2009 – september 2012
Methods: Review of medical records of infants hospitalized with pertussis reported in Oregon during a 44-month period.
Results: Reviewed 80 (92%) of the 87 medical charts. Median duration of hospitalization was 4 (range, 1128) days. Symptoms included cough (100%), paroxysms (90%), apnea (80%), posttussive vomiting (69%), and whoop (51%). Twenty (45%) developed pneumonia. Other complications included seizures (4 patients), pulmonary hypertension (2 patients), hemorrhages in the CNS and acute encephalopathy (1 patient). Supplemental oxygen was administered to 30 (38%) infants. Twenty-three (29%) infants were admitted to ICU; five required mechanical ventilation. Another infant was supported with extracorporeal membrane oxygenation for > 40 days. One infant <6 months old died. One patient was discharged on oxygen. Fifty-four (62%) of the infants were <2 months old. Of the 24 infants >2 months of age, 14 (58%) were unvaccinated, and 7 were appropriately vaccinated for their age.
Conclusions: Most of the suffering from pertussis is experienced by infants too young to be vaccinated. To reduce exposure to pertussis the best practices remain vaccination of all persons in close contact with infants, pregnant women during the last trimester, timely vaccination of infants, early treatment of cases and antibiotic prophylaxis around infants.
Public health or related research
Describe infants’ clinical presentation, course and severity of pertussis during hospital admissions. Identify the age groups where most of the severe disease occurs among infants Define best practices to reduce pertussis exposure among infants
Keyword(s): Public Health, Immunizations
Qualified on the content I am responsible for because: I work as epidemiologist with Oregon Public Health Division in communicable disease control with a main focus in vaccine preventable diseases. I am co-principal investigator of federally funded grants focusing on the epidemiology of pertussis and evaluation of pertussis vaccination in Oregon.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.