334821
Genetic testing uptake in hereditary breast-ovarian cancer syndrome and Lynch syndrome
Tuesday, November 3, 2015
Wei Zhuang, PhD,
Department of Preventive Medicine and Public Health, Creighton University, Omaha, NE
Mark Stacey, MS, MBA,
Department of Preventive Medicine and Public Health, Creighton University, Omaha, NE
Trudy Shaw, MA,
Department of Preventive Medicine and Public Health, Creighton University, Omaha, NE
Henry Lynch, MD,
Department of Preventive Medicine and Public Health, Creighton University, Omaha, NE
Background: Hereditary breast-ovarian cancer (HBOC) and Lynch syndrome (LS) are hereditary cancer predisposition syndromes. The estimated incidences of HBOC-associated breast cancer and LS-associated colorectal cancer (CRC) are 11,700-23,400 and 4,000-6,600, respectively in the United States for 2015. HBOC and LS are caused by germline genetic mutations. Mutation carriers warrant aggressive surveillance. We aim to describe the difference in DNA testing uptake between HBOC and LS over time. Methods: We studied a total of 475 individuals who were at risk of carrying the familial syndrome mutation and were invited by mail to undergo genetic testing from 1994 to 2014 from the Creighton University Hereditary Cancer Registry. The Generalized Estimating Equation model was used to investigate the chronological effect on the odds of genetic testing uptake among LS and HBOC families, adjusting for age and gender. Results: The odds of the genetic testing uptake in the HBOC group increased 1.17 times while the uptake odds in the LS group did not change over time (p-value = 0.020), adjusting for age and gender (p-values = 0.0085 and 0.0006, respectively). Conclusions: There was a significantly increased chronological effect on the genetic testing uptake odds among the HBOC families while the effect was not observed among the LS families, which could have been related to the increased publicity of HBOC and breast cancer. The increase of publicity and the development of a method to effectively and efficiently disseminate the knowledge and awareness of genetic testing for LS are warranted.
Learning Areas:
Biostatistics, economics
Communication and informatics
Implementation of health education strategies, interventions and programs
Provision of health care to the public
Public health or related education
Social and behavioral sciences
Learning Objectives:
Describe the difference in genetic testing uptake between hereditary breast-ovarian cancer syndrome and Lynch syndrome over time;
Identify the potential factors associated with the difference.
Keyword(s): Cancer, Genetics
Presenting author's disclosure statement:Qualified on the content I am responsible for because: More than ten years of collaborative and methodological research experience have allowed me to use my knowledge and skills to advance knowledge in personalized medicine, human genetics, human aging process, Parkinsonâs disease, and HIV-associated diseases. The training I received in the Biostatistics departments at Boston University and the University of Michigan, Ann Arbor allow me to work with other investigators to ensure a rigorous study design and accurate analysis.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines,
and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed
in my presentation.
