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Inflammation and functional decline in aging subjects from NHANES 2001 – 2010
Methods: C-reactive protein (mg/dL) was analyzed using quartiles developed from our dataset. Functional decline utilized five following constructs: Activities of daily living (ADL): Eating, walking, dressing getting out of bed; Instrumental activities of daily living (IADL): Managing money, housekeeping, food preparation; Leisure and social activities (LSA): Attending social events, going out to movies, in-home leisure activities; Lower extremity mobility (LEM): Walking for a quarter mile, walking up ten steps; General physical activities (GPA): Stooping, bending, standing, sitting, lifting, reaching, grasping. Logistic regression was performed for each type of decline utilizing CRP quartiles and adjusting for age and worse health than previous year. Odd ratios are reported.
Results: The highest quartile (4th quartile) of CRP was significant to < 0.0001: ADL: 1.82 (1.29 - 2.57); IADL: 2.06 (1.55 - 2.73); LSA: 2.65 (2.04 - 3.45); LEM: 3.33 (2.45 - 4.52); GPA: 2.66 (2.08 - 3.40). The second and third quartiles of CRP were also significant for LEM and GPA.
Conclusion: Elderly subjects with higher level of systemic inflammation, as measured by CRP, had decreased function on evaluated scales. With further study, CRP may be a useful clinical tool to aid clinicians in predicting functional decline in elderly patients.
Learning Areas:
Clinical medicine applied in public healthLearning Objectives:
Identify the relationship between inflammation and functional decline
Keyword(s): Aging, Medical Care
Qualified on the content I am responsible for because: I have three years experience analyzing population data for a state department of health. I teach secondary data analysis to graduate-level students.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.