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303790
Emotional Distress of Children with Cancer in China: An IRT Analysis of Pediatric PROMIS Anxiety and Depressive Symptoms Short Forms
Wednesday, November 19, 2014
Yanyan Liu, PhD candidate
,
School of Nursing, Second Military Medical University, Shanghai, China, Shanghai, China
Changrong Yuan, PhD
,
School of Nursing, Second Military Medical University, Shanghai, China, Shanghai, China
Jingting Wang, MSN
,
School of Nursing, Second Military Medical University, Shanghai, China., Shanghai, China
Pamela Hinds
,
School of Medicine, Children’s National Medical Center, The George Washington University, Washington, Washington, DC
The Pediatric Patient-Reported Outcomes Measurement Information System (PROMIS) was developed to assess self-reported quality of life and symptoms for children and adolescents experiencing a chronic illness. Eight Pediatric PROMIS short forms have been translated into Chinese and applied in children with cancer in China. This study aimed to describe the psychometric properties of two pediatric PROMIS emotional distress scales -- the Anxiety and Depressive symptoms scales. A total of 232 children and adolescents with cancer were recruited from both inpatient and outpatient clinics in two cities (Shanghai and Chengdu). Categorical confirmatory factor analysis (CCFA) was conducted to assess scale dimensionality and item local independence of the symptom items; and the Multiple Indicator Multiple Cause (MIMIC) model was used to assess Differential Item Functioning (DIF). Item Response Theory (IRT) parameters were calculated from the item thresholds and factor loadings estimated from the CCFA model, and test information against T-scores was estimated for each of the scales. Our results confirmed that the Pediatric PROMIS Anxiety and Depressive symptoms short forms have valid factorial structures; DIF was not present in any item of the two scales for a continuous grouping variable (age) and a dichotomous grouping variable (gender); both the Anxiety and Depression scales have a high test reliability as long as their T-scores are not on the low or high extremes. Our findings provide evidence that the Chinese version of the two Pediatric PROMIS measures can be readily applied to measure emotional distress symptoms in children with cancer in China.
Learning Areas:
Biostatistics, economics
Diversity and culture
Public health or related nursing
Public health or related research
Learning Objectives:
Describe the pediatric version of PROMIS instrument.
Discuss the basics of IRT.
Discuss how to calculate IRT (discrimination and difficulty) parameters using the item thresholds and factor loadings estimated from a categorical confirmatory factor analysis (CCFA) model.
Demonstrate how to conduct CCFA in Mplus.
Keyword(s): Biostatistics, Methodology
Presenting author's disclosure statement:Qualified on the content I am responsible for because: I am professor at the George Washington University. I have been doing research in pulbic healt for more than 20 years.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines,
and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed
in my presentation.
