Comorbidity in HIV-positive patients: A comparative study of HIV- and non-HIV-related hospitalizations in Mississippi, 2010-2011
BACKGROUND: We sought to delineate the demographic differences and to compare the comorbidity level among patients hospitalized with an HIV diagnosis and those hospitalized for all other causes in Mississippi during 2010-2011. We further evaluated the association between HIV-positive status and each of the sixteen studied non-AIDS-defining conditions. METHODS: We analyzed hospital discharge data and implemented the Charlson Comorbidity Index to compute the comorbidity scores. We compared proportions and determined the association between categorical variables with chi-square tests. Means were compared with a t-test. RESULTS: There were 3,692 HIV-related hospitalizations among the 768,602 reported hospitalizations. Compared with non-HIV-infected patients, HIV-infected patients were more likely to be younger (43.9 years versus 50.2 years, p < .001), males (56.7% versus 40.1%, p < .001), African-Americans (79.4% versus 37.3% p < .001), and urban residents (52.6% versus 39.5%, p < .001). Comorbidity evaluation revealed that 48.9% of all HIV-related discharges and 44.7% of all other discharges had a Charlson score of ≥ 1 (p < .001). The leading comorbidities among the HIV-positive patients were moderate/severe renal disease (17.9%), chronic pulmonary disease (12.6%), and non-complicated diabetes (11.2%). Three out of the sixteen examined comorbidities were significantly associated with an HIV-related diagnosis: moderate/severe renal disease (17.9% versus 8.8%), mild liver disease (2% versus 0.9 %), and moderate/severe liver disease (1% versus 0.6%). CONCLUSION: The HIV-positive patients tended to be younger, but had a higher comorbidity score than the non-HIV-positive patients. Additionally, renal disease was a concomitant diagnosis in nearly one fifth of all HIV-related hospitalizations.
Chronic disease management and prevention
Public health or related public policy
Define demographic differences and comorbidity level among patients hospitalized with an HIV diagnosis and those hospitalized for all other causes in Mississippi during 2010-2011.
Evaluate the association between HIV-positive status and sixteen comorbid conditions.
Keyword(s): HIV/AIDS, Hospitals
Presenting author's disclosure statement:
Qualified on the content I am responsible for because: I am an epidemiologist with the Mississippi State Department of Health specialized in analyzing hospital discharge data. I also have special experience in medical research related to infectious diseases. I am a co-author of this study and have participated in its design, research, and data analysis.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines,
and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed
in my presentation.