285293
Tracing the evolution origin of novel bartonella across different host in Taiwan
Ting-Wei Chi,
Department of public health, China Medical University, Taichung, Taiwan
Yu-Ching Lan, PhD,
Department of Health Risk Management, China Medical University, Taichung, Taiwan
Kuan-Hua Chen,
Department of Health Risk Management, China Medical University, Taichung, Taiwan
Yi-Chen Yang,
Department of health risk management, China Medical University, Taichung, Taiwan
Yuan-Ting Lu,
Department of Health Risk Management, China Medical University, Taichung, Taiwan
Man-Yu Hsu,
Department of Health Risk Management, China Medical University, Taichung, Taiwan
Bacteria of the genus Bartonella are fastidious, Gram-negative and aerobic bacilli. Recently, Bartonella spp. seroprevalence is pretty high more than 30% in HIV positive patients, blood donors or injecting drug users in west countries. Throughout the climate changes, the increasing vector positive rate increasing the infectious risk in human. Therefore, the purpose of this study will try to understand the evolution situation in this one of the famous zoonotic agent Bartonella spp in Taiwan This study used systematic review and downloaded the Bartonella spp. sequences from different host in the GenBank. Phylogenetic analysis of gltA gene was approached for understanding the evolution relationship among host. The bootstrap value represented in 1000 for branch robustness statistical examination.
The Neighbor-joining tree of 53 gltA sequences with 245 bps length presented 9 clusters with mixed host species. Taiwan animals Common bent-wing bat and Grey shrew represented 2 monophyletic clades in this phylodynamic analysis. Tracing their origin were back to 69.39(6.58~781.17) and 94.64(5.69~1109.55) years respectively.
These works will help a lot for the zoonotic disease control, treatment and prevention systems and especially for the vaccine development.
Learning Areas:
Basic medical science applied in public health
Epidemiology
Public health biology
Learning Objectives:
Analyze molecular epidemiology of bartonella evolution in Taiwan animals Common bent-wing bat and Grey shrew.
Presenting author's disclosure statement:Qualified on the content I am responsible for because: I am the resistant student in this study for one year, and I focus on training evolution origin in Zoonotic Diseases.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines,
and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed
in my presentation.
