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APHA Scientific Session and Event Listing

Recorded presentation

Naomi M. Gades, DVM, MS¹, Debra J. Jacobson, MS², Michaela E. McGree, BS², Rosebud O. Roberts, MD, MS¹, Michael M. Lieber, MD³, and Steven J. Jacobsen, MD, PhD¹. (1) Division of Epidemiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, 507-284-5544, gades.naomi@mayo.edu, (2) Division of Biostatistics, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, (3) Department of Urology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905

The Androgen Deficiency in Aging Males (ADAM) questionnaire is commonly used to screen men for androgen deficiency. Data from the Olmsted County Study of Urinary Symptoms and Health Status among Men were used to examine associations between responses to the ADAM questionnaire and the number of repeats of androgen receptor gene CAG. During 1989-1991, 2115 Caucasian men ages 40-79 years were randomly selected from the Olmsted County, MN population; a subset of men (~25%) received a urologic examination. Men were genotyped for the number of CAG repeats in the androgen receptor gene and in the twelfth year of follow-up, the ADAM questionnaire was completed. Results were based on 353 out of 510 baseline and replacement men, who participated in a detailed urologic study in 1994 and had a completed ADAM questionnaire. The number of CAG repeats was correlated with the number of positive ADAM responses, r = 0.14, p = 0.008. CAG repeat lengths of 21-23 and < 21, compared with CAG repeat lengths ≥ 24 were inversely associated with regards to lack of energy; age-adjusted odds ratio (OR) 0.57 (95% Confidence Interval) (CI 0.33, 0.98) and OR 0.47 (CI 0.26, 0.83), respectively. Similarly, CAG repeat lengths < 21 compared with CAG repeat lengths ≥ 24 were inversely associated with regards to decreased libido; age-adjusted OR 0.43 (CI 0.24, 0.76). While the underlying biologic mechanisms are unclear, androgen receptor gene CAG repeats are associated with how men respond to the ADAM questionnaire, potentially through hormonal mechanisms.

Learning Objectives:

• Discuss the androgen receptor gene polymorphisms, CAG.
• Review the ADAM questionnaire.
• Discuss the association between androgen gene polymorphisms, CAG and positive responses to the ADAM questionnaire.

Presenting author's disclosure statement:

Any relevant financial relationships? No

Recorded presentation