Back to Annual Meeting Page		American Public Health Association 133rd Annual Meeting & Exposition December 10-14, 2005 Philadelphia, PA

Abstract #109173

Adebowale Awosika-Olumo, MD, MS, MPH¹, Wesley McNeely, MS, MPH¹, Raouf R. Arafat, MD, MPH¹, James T. Gomez, BS², and Lydwina Anderson². (1) Bureau of Epidemiology, Office of Surveillance and Public Health Preparedness, Houston Department of Health and Human Services, 8000 N Stadium Dr 4th floor, Houston, TX 77054, 713-794-9181, awosika-olumo.adebowale@cityofhouston.net, (2) City of Houston Department of Health and Human Services, Bureau of Epidemiology, Office of Surveillance and Public Health Preparedness, 8000 N. Stadium Drive, Houston, TX 77054

Objective

To examine the risk factors associated with the increase in toxoplasmosis among the Houston HIV/AIDS population.

Method

Using data from the Houston site of the Adult/Adolescent Spectrum of HIV/AIDS Disease (ASD) (n= 5272). A nested case control design using multivariate unconditional logistic regression to build a model with appearance of toxoplasmosis as the dependant variable and non-US birth as the primary independent variable while controlling for common confounders.

Results:

Two multivariate models were developed, differing only in the inclusion of an interaction term. Model "A" showed the adjusted relative odds of a foreign born HIV(+) acquiring toxoplasmosis was 1.94 (P<0.05) when compared to US-born patients. Hispanic race was a significant risk factor with an OR of 1.73 (P<0.001). Low quality HAART cut the risk nearly in half (OR .043<0.61<.086) while high- quality HAART was 30 times more effective than no HAART at preventing disease (OR .01 <0.03<0.24; P <0.001). Antibiotic therapy showed beneficial though less dramatic effects: Low quality therapy reduced the risk by more than 20% (OR 0.61<0.77<0.98; P<.035) while high quality therapy cut the risk in half (OR 0.27<0.49<0.88; P<0.018). Model B added an interaction term to Model A to demonstrate the effect of 5 year age group on the dependant variable. This model revealed a striking association between youth and disease among foreign-born patients: inclusion of the interaction term modified the coefficient of the dependant variable by increasing it from 0.663 (0.329, 0.997) to 2.29 (1.22, 3.36) with a new odds ratio of 9.88

Learning Objectives:

• To examine the risk factors associated with the increase in toxoplasmosis among the Houston HIV/AIDS population.

Keywords: Risk Factors, HIV/AIDS

Presenting author's disclosure statement:

I wish to disclose that I have NO financial interests or other relationship with the manufactures of commercial products, suppliers of commercial services or commercial supporters.