Recorded presentation

Farnaz Vahidnia, MD, MPH¹, Brenda Eskenazi, PhD², and Nick Jewell, PhD². (1) School of Public Health, University of California at Berkeley, 140 Warren Hall, Berkeley, CA 94720-7360, 510-643-4284, fvahid@uclink.berkelely.edu, (2) Center for Children's Environmental Health Research, University of California, Berkeley, 2150 Shattuck Ave, Suite 600, Berkeley, CA 94720-7380

The authors evaluated the effect of maternal cigarette smoking and alcohol drinking as a possible risk factor for febrile convulsion in a large cohort of pregnant women. Participants included 11,826 women enrolled in the Child Health and Development Studies in California between 1959 and 1966. Women were divided into non-smokers (n= 7,587) and smokers (n= 4,239). Unadjusted odds ratio (OR) for smoking showed increased risk of febrile convulsion (OR= 1.20, 95% CI = 0.93, 1.55) that did not vary across levels of cigarette smoking (p-value for the trend = 0.99). Cox proportional hazard model, which assumed changes in hazard function with time, indicated that children of smokers are at a greater risk of febrile convulsion than those of non-smokers during the first 800 days of life, after adjusting for maternal alcohol drinking, husband smoking during pregnancy, infant�s sex, birth weight, severe congenital anomaly, and history of diarrhea and otitis media (OR = 1.37, 95% CI = 1.01, 1.87). The results also showed 2.1 times greater hazard associated with maternal smoking among children of those who are heavy drinkers (95% CI = 1.31, 3.26) during the first 800 days.

Learning Objectives: At the end of the session, the participitant will be able to

• Define Cox Proportional Hazard Model
• Describe the risk factors associated with children's febrile convulsion
• Recognize the association between maternal smoking and/or drinking and febriel convulsion

Keywords: Pregnancy, Smoking

Presenting author's disclosure statement:
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.

Recorded presentation