|
|
|
|
|
Amy K. Ferketich, PhD, Division of Epidemiology and Biometrics, The Ohio State University School of Public Health, B-116 Starling-Loving Hall, 320 West 10th Avenue, Columbus, OH 43210, 614-293-4387, ferketich.1@osu.edu and Philip F. Binkley, MD, Department of Internal Medicine, Division of Cardiology, The Ohio State University, 110 Davis Heart and Lung Research Institute, 473 West 12th Ave, Columbus, OH 43210.
Heart failure is thought to comprise an inflammatory component, for example elevated levels of proinflammatory cytokines, C-reactive protein (CRP), and fibrinogen. However, these associations are confounded by the significant proportion of patients with atherosclerosis, which itself has been associated with increased levels of inflammatory markers. In the present study, the association between inflammatory markers and non-ischemic heart failure is examined in a large population-based cohort. Data from participants over age 40 in NHANES III were analyzed. The main outcomes were elevated CRP and fibrinogen. The primary independent variable was non-ischemic heart failure. In fully adjusted logistic regression model, there was an effect of heart failure on CRP, with an odds ratio (OR) of 2.15 (95% CI 1.28–3.64, p=0.0049). A similar increase in the OR was found in the models examining fibrinogen, with the fully adjusted OR of 2.26 (95% CI 1.39–3.69, p=0.0016). There was a significant interaction between heart failure and race on elevated fibrinogen (p=0.0019). The effect of heart failure among non-Hispanic whites was 3.23 (95% CI 1.67-6.25), whereas it was 0.53 (95% CI 0.22-1.28) among non-Hispanic blacks and 1.27 (95% CI 0.70-2.28) among Hispanics. The results indicate that participants with self-reported non-ischemic heart failure have a greater odds of having elevated levels of CRP and fibrinogen, compared to participants without heart failure. There was also a statistically significant interaction between race and heart failure on levels of fibrinogen. While there was a strong effect among non-Hispanic whites, there was no effect among non-Hispanic blacks and Hispanics.
Learning Objectives:
Keywords: Heart Disease,
Presenting author's disclosure statement:
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.