Julie C. McLaughlin, MS, MPH¹, Aruna V. Sarma, PhD¹, Rodney Dunn, MS¹, Kathleen A. Cooney, MD¹, James E. Montie, MD², John T. Wei, MD³, and David Schottenfeld, MD⁴. (1) Urology, University of Michigan, 1016 Women's Trailer, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, 734-663-7428, juliecm@med.umich.edu, (2) Urology Surgery, University of Michigan, 2916 TC, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, (3) Department of Surgery/Urology, The University of Michigan, 2916 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0330, (4) Department of Epidemiology, School of Public Health, The University of Michigan, 109 S. Observatory, Ann Arbor, MI 48109-2029

Diabetes is the seventh leading cause of death among African-American men, and the age-standardized prevalence of diabetes is 1.5 times greater among African-American men than white. The high prevalence of obesity among African-American men as compared to whites, may in part account for the increased incidence and prevalence of diabetes among black men. The objective of the current study was to examine the associations between lifetime changes in body mass index (BMI) and self-reported diabetes in a cross-sectional analysis of a population-based sample of 817 African-American men aged 40-79. We found 81 percent of men with self-reported diabetes were currently overweight or obese (BMI &ge25kg/m2). Fifty-one percent of men who reported being overweight at age 25, were currently obese (BMI &ge30kg/m2). Seventy percent of men who reported being overweight at age 45, continued to be obese at their current age. In multivariate analyses controlling for age, hypertension, history of myocardial infarction, smoking status, alcohol consumption status and current BMI, men with BMI 30-39kg/m2 at age 25 had 2.8 [95 percent confidence interval (CI) (1.4, 5.4)] fold the odds of diabetes as compared to men whose BMI was <25kg/m2. Similarly, men with a BMI &ge40kg/m2 at age 25 had 17.8 [95% CI (1.1, 294.0)] the odds of diabetes. Our results suggest that being obese early in adulthood further increases the odds of African-American men developing diabetes later in life,and warrants further investigation of these relationships in future longitudinal studies.

Learning Objectives:

• At the conclusion of the session, the participant in this session will be able to discuss how elevated BMI in early adulthood can increase one's odds of developing diabetes later in life.

Presenting author's disclosure statement:
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.