Mycobacterium ulcerans (M. ulcerans) infection is rapidly emerging as an important cause of human morbidity throughout the world. The mode of transmission for M. ulcerans infection remains largely unknown and requires further investigation. This study describes a series of 85 cases of M. ulcerans infection during 1987-99 in a village in Ghana, West Africa. It also compares the occurrence of certain risk factors between cases and geographically matched controls. Fifty-two (24%) of the 215 households in the community were affected. The highest rate of disease was in the 0-9 year old age group, which constituted 44.7% of male and 52.6% of female cases. In children and adults alike, M. ulcerans infection predominately affected the extremities. Eleven (13%) of the cases interviewed suffered minor to severe deformities. Twenty-nine of the 85 cases, resulting in 7.5% of cases, lived in a residence area known as the Mission and 3.5% lived elsewhere in the village. Cases were significantly more likely to reside in the Mission (Chi-square=11.07, P=.0009). Water sources and footpath usage were also associated with higher incidence rates. Applicable preventative measures and mode of transmission possibilities require additional research. Further research also needs to be conducted among patients < 15 years old.
Learning Objectives: At the conclusion of the presentation, the participant will be able to:
Keywords: Emerging Diseases, Field Experience
Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: None
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.