Significance: Fibromyalgia syndrome (FMS) is an increasingly prevalent neuromusculoskeletal illness. The American College of Rheumatology characterizes FMS primarily by multiple body tenderpoints, nonrestful sleep and depression. Research to date has focused on isolated causal factors, with a lack of convincing results. A multifactorial etiologic investigation is necessary to uncover possible interacting causative variables. Methods: A case series of 40 men and women of various national origins with FMS were individually interviewed. Questions focused on life events, medical and family history, treatments and personal perspectives. In addition, published theories FMS etiology were addressed, including infections, trauma, heredity, toxins, and psychological theories. Qualitative, quantitative and multivariate analysis were performed. Results: Interview responses demonstrate less then 16% of subjects have risk factors consistent with only one etiologic theory. More than 86% support multiple etiologic theories. Patient perspectives support a "stress" component in the development FMS. Conclusion: Patients with FMS develop their condition from more than one causal factor. The most common interacting variables are a history of trauma, hereditary pattern of FMS, and psychological stress, all three occurring together in over 72% of subjects. A new etiological paradigm for FMS, including multiple risk factors, must be considered for effective prevention and treatment
Learning Objectives: N/A
Keywords: Etiology, Psychological Indicators
Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: None
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.