Although the characteristics of multiple sclerosis (MS) were first described over 100 years ago, relatively little progress has been made in identifying its etiology. There is little evidence for a single cause of MS; findings from epidemiological studies provide evidence for both the genetic and environmental components of susceptibility. The genetic component of MS is supported by studies showing MS to be more common in relatives of patients than in the general population, and in certain ethnic groups. The environmental component is supported by studies showing that the prevalence of MS varies by geographical location, generally increasing with distance from the equator, and that migration may alter the risk of occurrence of MS, depending on the age at migration. Other environmental factors, including heavy metals, viruses, and hormones, are also hypothesized to play a role in the development of this disease.
This presentation will provide an overview of the earlier etiologic hypotheses and discuss the current state of knowledge about the potential cause(s) of MS. In addition, the presentation will highlight some of the methodological limitations of previous research in this area. Recommendations for conducting future epidemiologic research of a rare disease with suspected genetic and environmental components will be provided.
Learning Objectives: N/A
Keywords: Women's Health, Epidemiology
Presenting author's disclosure statement:
Organization/institution whose products or services will be discussed: None
I do not have any significant financial interest/arrangement or affiliation with any organization/institution whose products or services are being discussed in this session.